Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0A2RA
|
||||
| Former ID |
DCL000310
|
||||
| Drug Name |
TAK-491
|
||||
| Synonyms |
TAK 491
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Phase 3 | [525243] | ||
| Company |
Takeda
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C30H24N4O8
|
||||
| Canonical SMILES |
CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)<br />ON5)C(=O)OCC6=C(OC(=O)O6)C
|
||||
| InChI |
1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)
|
||||
| InChIKey |
QJFSABGVXDWMIW-UHFFFAOYSA-N
|
||||
| CAS Number |
CAS 147403-03-0
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
16432925, 42318397, 78722900, 124490300, 134213327, 134339084, 134339085, 135252032, 135268988, 137006755, 137156369, 138302391, 138841269, 160645952, 160678326, 162009738, 162011695, 162202012, 162224719, 163399442, 163620811, 163686137, 164780184, 172918179, 174530959, 175266956, 175427104, 178103482, 185979066, 189628660, 223963164, 225354591, 226977592, 244206077, 245963438, 252067956, 252225336, 252319154, 252449179
|
||||
| Target and Pathway | |||||
| Target(s) | Type-1 angiotensin II receptor | Target Info | Modulator | [531783] | |
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Pathway Interaction Database | Arf6 trafficking events | ||||
| Arf6 signaling events | |||||
| Angiopoietin receptor Tie2-mediated signaling | |||||
| PathWhiz Pathway | Angiotensin Metabolism | ||||
| Muscle/Heart Contraction | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.