Drug General Information
Drug ID	D0A2IH
Former ID	DIB013879
Drug Name	KU-1257
Drug Type	Small molecular drug
Indication	Duodenal ulcers [ICD10:K25-K27]		Discontinued in Phase 3	[545005]
Company	Kyorin Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C18H29N3O2
Canonical SMILES	C(=O)(NCCCOc1cc(CN2CCCCC2)ccc1)NCC
CAS Number	CAS 120958-90-9
PubChem Compound ID	129319
Target and Pathway
Target(s)	Histamine H2 receptor	Target Info	Antagonist	[533888]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway	Intracellular Signalling Through Histamine H2 Receptor and Histamine
	Gastric Acid Production
Reactome	Histamine receptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545005	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001852)
Ref 533888	Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea. Arzneimittelforschung. 1993 Feb;43(2):129-33.

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