Drug Information

Drug General Information
Drug ID
D0A1LS
Former ID
DIB012915
Drug Name
Genz-644282
Synonyms
Genz-644283; Anticancer compound (cancer), Genzyme
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [522733]
Company
Genzyme Corp
Structure
Download
2D MOL

3D MOL
Formula
C22H21N3O5
Canonical SMILES
CNCCN1C2=C(C=NC3=CC4=C(C=C32)OCO4)C5=CC(=C(C=C5C1=O)OC)<br />OC
InChI
1S/C22H21N3O5/c1-23-4-5-25-21-14-8-19-20(30-11-29-19)9-16(14)24-10-15(21)12-6-17(27-2)18(28-3)7-13(12)22(25)26/h6-10,23H,4-5,11H2,1-3H3
InChIKey
BAORCAMWLWRZQG-UHFFFAOYSA-N
PubChem Compound ID
10294813
PubChem Substance ID
15301494, 22669559, 35612128, 77048758, 103465070, 141766551, 172650165, 185990524, 198972215, 210275488, 210281136, 226592146, 245240873, 248395854, 252160817, 252451615
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [531401]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 522733ClinicalTrials.gov (NCT00942799) Dose Escalation Study to Assess the Safety and Tolerability of Genz-644282 in Patients With Solid Tumors. U.S. National Institutes of Health.
Ref 531401Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17(9):2777-87.

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