Drug Information
Drug General Information | |||||
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Drug ID |
D09ZVC
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Former ID |
DIB010369
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Drug Name |
Begacestat
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Synonyms |
GSI-953; PF-05212362; PF-5212362; WAY-201953; WAY-210953
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Drug Type |
Small molecular drug
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Company |
Wyeth
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Structure |
Download2D MOL |
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Formula |
C9H8ClF6NO3S2
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InChI |
InChI=1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1
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InChIKey |
PSXOKXJMVRSARX-SCSAIBSYSA-N
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CAS Number |
CAS 769169-27-9
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Gamma-secretase | Target Info | Modulator | [530308] | |
KEGG Pathway | Notch signaling pathway | ||||
Alzheimer's disease | |||||
Reactome | Nuclear signaling by ERBB4 | ||||
Regulated proteolysis of p75NTR | |||||
NRIF signals cell death from the nucleus | |||||
Activated NOTCH1 Transmits Signal to the Nucleus | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
NOTCH2 Activation and Transmission of Signal to the Nucleus | |||||
EPH-ephrin mediated repulsion of cells | |||||
References | |||||
Ref 530308 | Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. | ||||
Ref 542009 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6979). |
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