Drug General Information
Drug ID	D09ZSK
Former ID	DNC005451
Drug Name	N-(5-Phenyl-furan-2-carbonyl)-guanidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527509]
Structure		Download 2D MOL 3D MOL
Formula	C12H11N3O2
Canonical SMILES	C1=CC=C(C=C1)C2=CC=C(O2)C(=O)N=C(N)N
InChI	1S/C12H11N3O2/c13-12(14)15-11(16)10-7-6-9(17-10)8-4-2-1-3-5-8/h1-7H,(H4,13,14,15,16)
InChIKey	SYROHGCLRGCTIR-UHFFFAOYSA-N
PubChem Compound ID	11470226
Target and Pathway
Target(s)	Sodium/hydrogen exchanger 1	Target Info	Inhibitor	[527509]
KEGG Pathway	cAMP signaling pathway
	Cardiac muscle contraction
	Adrenergic signaling in cardiomyocytes
	Regulation of actin cytoskeleton
	Thyroid hormone signaling pathway
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretion
	Proteoglycans in cancer
Pathway Interaction Database	Endothelins
	RhoA signaling pathway
	ErbB1 downstream signaling
	Signaling mediated by p38-alpha and p38-beta
Reactome	Hyaluronan uptake and degradation
WikiPathways	Regulation of Actin Cytoskeleton
	G Protein Signaling Pathways
	Glycosaminoglycan metabolism
	Osteoclast Signaling
References
Ref 527509	J Med Chem. 2005 Apr 21;48(8):2882-91.(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1.
Ref 527509	J Med Chem. 2005 Apr 21;48(8):2882-91.(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1.

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