Drug Information

Drug General Information
Drug ID
D09WYX
Former ID
DNAP001529
Drug Name
Deflazacort
Synonyms
Deflan (TN)
Drug Type
Small molecular drug
Indication Duchenne muscular dystrophy [ICD10:G71.0] Approved [524244], [551871], [889446]
Company
Ptc Therap
Structure
Download
2D MOL

3D MOL
Formula
C25H31NO6
Canonical SMILES
CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)C<br />OC(=O)C
InChI
1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3
InChIKey
FBHSPRKOSMHSIF-UHFFFAOYSA-N
CAS Number
CAS 14484-47-0
PubChem Compound ID
26709
PubChem Substance ID
29293537, 50019505, 57310307, 78434559, 81041118, 104298055, 125341126, 126667087, 136298778, 137231389, 163133908, 164788299, 223659443, 226396091, 251887654
SuperDrug ATC ID
H02AB13
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Modulator [556264]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 524244ClinicalTrials.gov (NCT01817322) Kidney Graft Function Under the Immunosuppression Strategies. U.S. National Institutes of Health.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 889446Drugs@FDA (Edaravone)
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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