Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09WSG
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| Former ID |
DNC008135
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| Drug Name |
Salvinorin B benzyloxymethyl ether
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C29H34O8
|
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| Canonical SMILES |
CC12CCC3C(=O)OC(CC3(C1C(=O)C(CC2C(=O)OC)OCOCC4=CC=CC=C4<br />)C)C5=COC=C5
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| InChI |
1S/C29H34O8/c1-28-11-9-20-27(32)37-23(19-10-12-34-16-19)14-29(20,2)25(28)24(30)22(13-21(28)26(31)33-3)36-17-35-15-18-7-5-4-6-8-18/h4-8,10,12,16,20-23,25H,9,11,13-15,17H2,1-3H3/t20-,21-,22-,23-,25-,28-,29-/m0/s1
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| InChIKey |
UEIIMJAHRTUJMW-ZZIVESEQSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Kappa-type opioid receptor | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Opioid prodynorphin pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. Epub 2007 Oct 24.Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. | ||||
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