Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09VGC
|
||||
| Former ID |
DAP001155
|
||||
| Drug Name |
Milnacipran
|
||||
| Synonyms |
Ixel; Midalcipran; Milnacipranum; Toledomin; Milnacipran [INN]; Milnacipranum [Latin]; F 2207; F-2207; Ixel (TN); Milnacipran(INN); Savella (TN); (+-)-cis-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide; (-)-Milnacipran; (-)-milnacipran; (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide; 1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane HCl
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Depression [ICD9: 311; ICD10:F30-F39] | Approved | [1], [2] | ||
| Therapeutic Class |
Antidepressants
|
||||
| Company |
Silesia Laboratories
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C15H22N2O
|
||||
| InChI |
InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3
|
||||
| InChIKey |
GJJFMKBJSRMPLA-UHFFFAOYSA-N
|
||||
| CAS Number |
CAS 92623-85-3
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| SuperDrug ATC ID |
N06AX17
|
||||
| SuperDrug CAS ID |
cas=092623853
|
||||
| Target and Pathway | |||||
| Target(s) | Sodium-dependent noradrenaline transporter | Target Info | Inhibitor | [3] | |
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| References | |||||
| REF 1 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7436). | ||||
| REF 3 | Milnacipran: Beyond a Role of Antidepressant. Clin Neuropharmacol. 2009 Jun 10. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.