Drug Information

Drug General Information
Drug ID
D09TYM
Former ID
DNC004402
Drug Name
LEUKOTRIENE_B4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551272]
Structure
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2D MOL

3D MOL
Formula
C20H32O4
Canonical SMILES
CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O
InChI
1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
InChIKey
VNYSSYRCGWBHLG-AMOLWHMGSA-N
PubChem Compound ID
5280492
Target and Pathway
Target(s) Leukotriene B4 receptor 2 Target Info Inhibitor [551245]
Leukotriene B4 receptor 1 Target Info Inhibitor [551272]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP80:Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Spinal Cord Injury
References
Ref 551272Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994).
Ref 551245Diaryl ether/carboxylic acid derivatives of LY255283: Receptor antagonists of leukotriene B4, Bioorg. Med. Chem. Lett. 3(10):1985-1990 (1993).
Ref 551272Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994).

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