Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D09TDZ
|
||||
Former ID |
DIB002343
|
||||
Drug Name |
AF-802
|
||||
Synonyms |
CH-5424802; ALK inhibitor (NSCLC), Chugai
|
||||
Drug Type |
Small molecular drug
|
||||
Company |
Chugai pharma; Roche
|
||||
Formula |
C30H34N4O2
|
||||
InChI |
InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
|
||||
InChIKey |
KDGFLJKFZUIJMX-UHFFFAOYSA-N
|
||||
PubChem Compound ID | |||||
PubChem Substance ID |
103778663, 121116820, 123050635, 124968641, 136345847, 136367502, 136966843, 144115816, 152159573, 152255079, 152258416, 160647252, 162011594, 162205135, 163643281, 164041825, 174006440, 174526912, 185973183, 198968336, 223366072, 223382853, 223705048, 224579110, 227163650, 242060208, 249734006, 249814476, 252110120, 252151320, 252160538, 252215127, 252444922, 252451665, 252811243
|
||||
Target and Pathway | |||||
Target(s) | ALK tyrosine kinase receptor | Target Info | Inhibitor | [531479] | |
KEGG Pathway | Non-small cell lung cancer | ||||
WikiPathways | Differentiation Pathway | ||||
References | |||||
Ref 524315 | ClinicalTrials.gov (NCT01871805) A Study of CH5424802/RO5424802 in Patients With ALK-Rearranged Non-Small Cell Lung Cancer. U.S. National Institutes of Health. | ||||
Ref 542705 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7739). |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.