Drug General Information
Drug ID
D09TDZ
Former ID
DIB002343
Drug Name
AF-802
Synonyms
CH-5424802; ALK inhibitor (NSCLC), Chugai
Drug Type
Small molecular drug
Indication Non-small cell lung cancer [ICD10:C33-C34] Phase 2 [524315], [542705]
Company
Chugai pharma; Roche
Formula
C30H34N4O2
InChI
InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
InChIKey
KDGFLJKFZUIJMX-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) ALK tyrosine kinase receptor Target Info Inhibitor [531479]
KEGG Pathway Non-small cell lung cancer
WikiPathways Differentiation Pathway
References
Ref 524315ClinicalTrials.gov (NCT01871805) A Study of CH5424802/RO5424802 in Patients With ALK-Rearranged Non-Small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 542705(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7739).
Ref 531479CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011 May 17;19(5):679-90.

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