| Drug General Information |
| Drug ID |
D09PXU
|
| Former ID |
DNC006327
|
| Drug Name |
4,7-dimethyl-6H-benzo[c]chromene-3,8-diol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H14O3
|
| Canonical SMILES |
CC1=C(C=CC2=C1COC3=C2C=CC(=C3C)O)O
|
| InChI |
1S/C15H14O3/c1-8-12-7-18-15-9(2)14(17)6-4-11(15)10(12)3-5-13(8)16/h3-6,16-17H,7H2,1-2H3
|
| InChIKey |
UCANDFJLKWPIBP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Estrogen receptor beta |
Target Info |
Inhibitor |
[1]
|
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| Estrogen receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Estrogen signaling pathway
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Prolactin signaling pathwayhsa04915:Estrogen signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Endocrine and other factor-regulated calcium reabsorption
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Proteoglycans in cancer
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NetPath Pathway
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FSH Signaling Pathway
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EGFR1 Signaling Pathway
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RANKL Signaling Pathway
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
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Validated nuclear estrogen receptor beta network
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Validated nuclear estrogen receptor alpha networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by HDAC Class II
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LKB1 signaling events
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Regulation of Telomerase
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ATF-2 transcription factor network
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AP-1 transcription factor network
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FOXM1 transcription factor network
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Validated nuclear estrogen receptor alpha network
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Signaling mediated by p38-alpha and p38-beta
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FOXA1 transcription factor network
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Reactome
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Nuclear Receptor transcription pathwayR-HSA-1251985:Nuclear signaling by ERBB4
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Nuclear Receptor transcription pathway
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WikiPathways
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SIDS Susceptibility Pathways
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Ovarian Infertility Genes
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Integrated Pancreatic Cancer Pathway
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Nuclear ReceptorsWP712:Estrogen signaling pathway
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Nuclear Receptors Meta-Pathway
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Estrogen Receptor Pathway
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Signaling by ERBB4
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JAK/STAT
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Leptin signaling pathway
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miR-targeted genes in muscle cell - TarBase
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Integrated Breast Cancer Pathway
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Nuclear Receptors
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| References |
| REF 1 | Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. Epub 2006 Jan 18.6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. |
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