Drug Information

Drug General Information
Drug ID
D09PSB
Former ID
DIB009682
Drug Name
DPC-082
Synonyms
(E)-4(S)-(2-Cyclopropylvinyl)-5,6-difluoro-4-(trifluoromethyl)-3,4-dihydro-1H-quinazolin-2-one; 214287-98-6
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 1 [547216]
Structure
Download
2D MOL

3D MOL
Formula
C14H11F5N2O
Canonical SMILES
C1CC1C=CC2(C3=C(C=CC(=C3F)F)NC(=O)N2)C(F)(F)F
InChI
1S/C14H11F5N2O/c15-8-3-4-9-10(11(8)16)13(14(17,18)19,21-12(22)20-9)6-5-7-1-2-7/h3-7H,1-2H2,(H2,20,21,22)/b6-5+/t13-/m0/s1
InChIKey
JUCDJPCFPITYRP-GFUIURDCSA-N
CAS Number
CAS 214287-98-6
PubChem Compound ID
6451134
PubChem Substance ID
630417, 11972324, 14801299, 24714767, 43042104, 57370272, 78910449, 103252600, 114526456, 135246150
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [525645], [551871]
References
Ref 547216Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014106)
Ref 525645Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 1999 Dec;43(12):2893-7.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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