Drug General Information
Drug ID
D09POQ
Former ID
DIB004377
Drug Name
OM-174
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [524222]
Company
OM Pharma
Structure
Download
2D MOL

3D MOL

Formula
C53H102N2O20P2
CAS Number
CAS 171092-39-0
PubChem Compound ID
Target and Pathway
Target(s) Toll-like receptor 4 Target Info Modulator [532290]
Toll-like receptor 2 Target Info Modulator [532290]
KEGG Pathway NF-kappa B signaling pathway
HIF-1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Influenza A
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritishsa04145:Phagosome
Herpes simplex infection
Rheumatoid arthritis
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling PathwayNetPath_16:IL4 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signalingtoll_endogenous_pathway:Endogenous TLR signaling
Reactome Ligand-dependent caspase activation
Toll Like Receptor 4 (TLR4) Cascade
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent TLR3/TLR4 cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complexR-HSA-1461957:Beta defensins
Toll Like Receptor TLR6:TLR2 Cascade
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent cascade
Primary Focal Segmental Glomerulosclerosis FSGS
Spinal Cord Injury
Corticotropin-releasing hormone
Pathogenic Escherichia coli infection
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
IL1 and megakaryotyces in obesity
Human Complement System
Defensins
Regulation of toll-like receptor signaling pathway
References
Ref 524222ClinicalTrials.gov (NCT01800812) Effects of OM-174 in Adult Patients With Solid Tumors. U.S. National Institutes of Health.
Ref 532290Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013 Apr 2;13:172.

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