Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09PKU
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| Former ID |
DIB015895
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| Drug Name |
ERBULOZOLE
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| Synonyms |
BAN; Erbulozole < Rec INN; R-55104; Ethyl rac-cis-p-[[[2-(Imidazol-1-ylmethyl)-2-(p-methoxyphenyl)-1,3-dioxolan-4-yl]methyl]thio]carbanilate; Rac-cis-[4-[[2-((1H-Imidazol-1-ylmethyl)-2-(4-methoxyphenyl)-1,3-dioxolan-4-yl]methylthio]phenyl]carbamic acid ethyl ester
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| Drug Type |
Small molecular drug
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Discontinued in Phase 2 | [545429] | ||
| Structure |
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Download2D MOL |
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| Formula |
C24H27N3O5S
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| Canonical SMILES |
CCOC(=O)Nc1ccc(SCC2COC(Cn3ccnc3)(O2)c4ccc(OC)cc4)cc1
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| InChI |
1S/C24H27N3O5S/c1-3-30-23(28)26-19-6-10-22(11-7-19)33-15-21-14-31-24(32-21,16-27-13-12-25-17-27)18-4-8-20(29-2)9-5-18/h4-13,17,21H,3,14-16H2,1-2H3,(H,26,28)
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| InChIKey |
KLEPCGBEXOCIGS-UHFFFAOYSA-N
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| CAS Number |
CAS 124784-31-2
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Tubulin | Target Info | Modulator | [533220], [551871] | |
| References | |||||
| Ref 533220 | Influence of the synthetic microtubule inhibitor erbulozole (P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors in vivo. Eur J Cancer Clin Oncol. 1989 Oct;25(10):1499-504. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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