Drug Information
Drug General Information | |||||
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Drug ID |
D09OUT
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Former ID |
DIB010098
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Drug Name |
NN-818
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Synonyms |
Beta-amyloid precursor protein modulator (CNS disorders), NewNeural
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Indication | Brain injury [ICD10:S09.90] | Preclinical | [1] | ||
Company |
University of Illinois
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Target and Pathway | |||||
Target(s) | Amyloid beta A4 protein | Target Info | Modulator | [2] | |
KEGG Pathway | Notch signaling pathway | ||||
Alzheimer's disease | |||||
Reactome | Nuclear signaling by ERBB4 | ||||
Degradation of the extracellular matrix | |||||
Regulated proteolysis of p75NTR | |||||
NRIF signals cell death from the nucleus | |||||
Activated NOTCH1 Transmits Signal to the Nucleus | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
EPH-ephrin mediated repulsion of cells | |||||
WikiPathways | Notch Signaling Pathway | ||||
Signaling by ERBB4 | |||||
Signaling by NOTCH3 | |||||
Signaling by NOTCH4 | |||||
Signaling by NOTCH1 | |||||
Signaling by NOTCH2 | |||||
Notch Signaling Pathway | |||||
Alzheimers Disease | |||||
Signalling by NGF | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020811) | ||||
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). | ||||
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