Drug Information

Drug General Information
Drug ID
D09NBM
Former ID
DIB007427
Drug Name
SB-435495
Indication Arteriosclerosis [ICD9: 440; ICD10:I70] Discontinued in Phase 1 [547355]
Company
GlaxoSmithKline plc
Structure
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2D MOL

3D MOL
Canonical SMILES
n1(c(nc(=O)c(c1)Cc1cnn(c1)C)SCc1ccc(cc1)F)CC(=O)N(Cc1cc<br />c(cc1)c1ccc(cc1)C(F)(F)F)CCN(CC)CC
Target and Pathway
Target(s) Phospholipase A2 Target Info Inhibitor [532111]
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorption
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways Glycerophospholipid biosynthesis
References
Ref 547355Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015443)
Ref 532111The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. Respir Res. 2012 Nov 12;13:100.

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