Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09LWS
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| Former ID |
DAP000717
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| Drug Name |
Ezetimibe
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| Synonyms |
Ezedoc; Ezetimib; Ezetrol; Zetia; Zient; Essex brand of ezetimibe; MSD brand of ezetimibe; Merck brand of ezetimibe; SCH58235; Sch 58235; Ezetimibe [USAN:INN]; Inegy (TN); MK-0653; SCH-58235; Schering-Plough brand of ezetimibe; Vytorin (TN); Zetia (TN); Zetia , Ezetrol, Ezetimibe; Ezetimibe (JAN/USAN/INN); (-)-Sch 58235; (1-(4-fluorophenyl)-(3R)-(3-(4-fluorophenyl)-(3S)-hydroxypropyl)-(4S)-(4-hydroxyphenyl)-2-azetidinone); (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3R,4S)-1-(p-Fluorophenyl)-3-((3S)-3-(p-fluorophenyl)-3-hydroxypropyl)-4-(p-hydroxyphenyl)-2-azetidinone; 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-(4-hydroxyphenyl)-2-azetidione; 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anticholesteremic Agents
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| Company |
Schering-Plough
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| Structure |
|
Download2D MOL |
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| Formula |
C24H21F2NO3
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| InChI |
InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
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| InChIKey |
OLNTVTPDXPETLC-XPWALMASSA-N
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| CAS Number |
CAS 163222-33-1
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7849028, 10250673, 11528896, 12014979, 14879623, 14928749, 26719841, 46226990, 46386640, 46507625, 49681809, 49693660, 50539938, 53787196, 57347010, 71821424, 81146074, 92308446, 92718207, 103326446, 104179182, 104253290, 104428106, 117884262, 124658886, 124757411, 124801398, 125164215, 126592989, 126621626, 126653456, 126667079, 127315811, 127315812, 127315813, 127315814, 127315815, 127315816, 127315817, 127315818, 127315819, 127315820, 127315821, 127315822, 127315823, 127315824, 128826430, 131854738, 134338005, 135107180
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| ChEBI ID |
ChEBI:49040
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| SuperDrug ATC ID |
C10AX09
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| SuperDrug CAS ID |
cas=163222331
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| Target and Pathway | |||||
| Target(s) | Niemann-Pick C1-like protein 1 | Target Info | Inhibitor | [537517] | |
| KEGG Pathway | Fat digestion and absorption | ||||
| WikiPathways | Vitamin A and Carotenoid Metabolism | ||||
| References | |||||
| Ref 536740 | Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81. | ||||
| Ref 541898 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6816). | ||||
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