Drug General Information
Drug ID	D09KKF
Former ID	DNC002791
Drug Name	2-Amino-5-Hydroxy-Benzimidazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551393]
Structure		Download 2D MOL 3D MOL
Formula	C7H7N3O
Canonical SMILES	C1=CC2=NC(NC2=CC1=O)N
InChI	1S/C7H7N3O/c8-7-9-5-2-1-4(11)3-6(5)10-7/h1-3,7,10H,8H2
InChIKey	ZXXRHVCYZYWAHI-UHFFFAOYSA-N
PubChem Compound ID	6323183
PubChem Substance ID	7885044, 42972577, 50504433, 114480910
Target and Pathway
Target(s)	Urokinase-type plasminogen activator	Target Info	Inhibitor	[551393]
KEGG Pathway	NF-kappa B signaling pathway
	Complement and coagulation cascades
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
NetPath Pathway	IL2 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Blood coagulation
	Plasminogen activating cascade
	CCKR signaling map ST
Pathway Interaction Database	Beta1 integrin cell surface interactions
	E2F transcription factor network
	Beta3 integrin cell surface interactions
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	amb2 Integrin signaling
	ATF-2 transcription factor network
	AP-1 transcription factor network
	Beta2 integrin cell surface interactions
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
	FGF signaling pathway
Reactome	Dissolution of Fibrin Clot
WikiPathways	DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Complement and Coagulation Cascades
	Endochondral Ossification
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Blood Clotting Cascade
	Dissolution of Fibrin Clot
	Osteopontin Signaling
References
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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