Drug Information

Drug General Information
Drug ID
D09IMS
Former ID
DAP001078
Drug Name
Mequitazine
Synonyms
Butix; Instotal; Kitazemin; Mequitazina; Mequitazinum; Metaplexan; Mircol; Primalan; Quitadrill; Vigigan; Virginan; Zesulan; Italfarmaco brand of mequitazine; Mequitazina [Spanish]; Mequitazine hydrochloride; Pierre Fabre brand of mequitazine; LM 209; Kitazemin (TN); LM-209; Mequitazina [INN-Spanish]; Mequitazinum [INN-Latin]; Mequitazine (JP15/INN); Mequitazine [INN:BAN:DCF:JAN]; Mequitazine tartrate, (R-(R*,R*))-isomer; 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine; 10-(1-azabicyclo(2.2.2)oct-8-ylmethyl)phenothiazine; 10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine; 10-(3-Quinuclidinylmethyl)phenothiazine; 10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)-(9CI); 3-Methylquinuclidinyl-10-phenothiazine
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [550725]
Therapeutic Class
Antihistamines
Structure
Download
2D MOL

3D MOL
Formula
C20H22N2S
Canonical SMILES
C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53
InChI
1S/C20H22N2S/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21/h1-8,15-16H,9-14H2
InChIKey
HOKDBMAJZXIPGC-UHFFFAOYSA-N
CAS Number
CAS 29216-28-2
PubChem Compound ID
4066
PubChem Substance ID
453325, 583144, 7366094, 7848387, 8141047, 8152552, 10320045, 10517343, 11406959, 14850608, 16617285, 26665232, 29223177, 46505779, 48416221, 50006661, 53787706, 56320321, 57322124, 57962172, 78247115, 81093314, 85209426, 87244027, 92714662, 103267575, 103815311, 104305332, 104972177, 117404379, 124799813, 124894252, 125347181, 126623962, 126655271, 126669303, 128089981, 131309176, 134338335, 134997033, 137267684, 140724147, 142143428, 144207197, 160964405, 163121882, 164761785, 164814342, 170005238, 170465794
SuperDrug ATC ID
R06AD07
SuperDrug CAS ID
cas=029216282
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536811]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 550725Drug information of Mequitazine, 2008. eduDrugs.
Ref 536811Efficiency of mequitazine in the treatment of allergic rhinitis and chronic urticaria in children. A bibliographic systematic review. Rev Alerg Mex. 2008 Jan-Feb;55(1):3-9.

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