Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09HTB
|
||||
| Former ID |
DCL000635
|
||||
| Drug Name |
SAR153191
|
||||
| Indication | Ankylosing spondylitis [ICD9: 720; ICD10:M08.1, M45] | Phase 3 | [1], [2] | ||
| Company |
Sanofi-Aventis
|
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| Target and Pathway | |||||
| Target(s) | Interleukin-6 receptor | Target Info | Antagonist | [3] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| HIF-1 signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| Jak-STAT signaling pathway | |||||
| Hematopoietic cell lineage | |||||
| Non-alcoholic fatty liver disease (NAFLD) | |||||
| Reactome | MAPK3 (ERK1) activation | ||||
| MAPK1 (ERK2) activation | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Senescence and Autophagy in Cancer | |||||
| IL-6 signaling pathway | |||||
| Differentiation Pathway | |||||
| Interleukin-6 signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7999). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027858) | ||||
| REF 3 | Pharma & Vaccines. Product Development Pipeline. April 29 2009. | ||||
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