Drug General Information
Drug ID
D09FZI
Former ID
DIB013143
Drug Name
TALTOBULIN
Synonyms
HTI-286; SPA-110 (trifluoroacetate salt); Taltobulin < Prop INN >; N,3,3-Trimethyl-L-phenylalanyl-N1-[3-carboxy-1(S)-isopropyl-2(E)-butenyl]-N1,3-dimethyl-L-valinamide
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 1 [547769]
Structure
Download
2D MOL

3D MOL

Formula
C27H43N3O4
Canonical SMILES
CN[C@H](C(=O)N[C@H](C(=O)N(C)[C@H](\\C=C(/C)\\C(=O)O)C(<br />C)C)C(C)(C)C)C(C)(C)c1ccccc1
InChI
1S/C27H43N3O4/c1-17(2)20(16-18(3)25(33)34)30(10)24(32)22(26(4,5)6)29-23(31)21(28-9)27(7,8)19-14-12-11-13-15-19/h11-17,20-22,28H,1-10H3,(H,29,31)(H,33,34)/b18-16+/t20-,21-,22-/m1/s1
InChIKey
CNTMOLDWXSVYKD-PSRNMDMQSA-N
CAS Number
CAS 228266-40-8
PubChem Compound ID
Target and Pathway
Target(s) Tubulin Target Info Inhibitor [530691], [551871]
References
Ref 547769Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019128)
Ref 530691Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1535-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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