Drug Information

Drug General Information
Drug ID
D09FVG
Former ID
DNC013740
Drug Name
AKUAMMINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551355]
Structure
Download
2D MOL

3D MOL
Formula
C22H26N2O4
Canonical SMILES
CC=C1CN2CCC34C5=C(C=CC(=C5)O)N(C36C2CC1C4(CO6)C(=O)OC)C
InChI
1S/C22H26N2O4/c1-4-13-11-24-8-7-21-16-9-14(25)5-6-17(16)23(2)22(21)18(24)10-15(13)20(21,12-28-22)19(26)27-3/h4-6,9,15,18,25H,7-8,10-12H2,1-3H3/b13-4-/t15?,18-,20+,21?,22?/m0/s1
InChIKey
YILKZADAWNUTTB-OPAPVENDSA-N
CAS Number
CAS 3512-87-6
PubChem Compound ID
6441511
PubChem Substance ID
50753466, 57369201
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [551355]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 551355Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4.
Ref 551355Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4.

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