Drug General Information
Drug ID
D09FGQ
Former ID
DNC000588
Drug Name
E-64
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535267]
Structure
Download
2D MOL

3D MOL

Formula
C15H27N5O5
Canonical SMILES
CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
InChI
1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)
InChIKey
LTLYEAJONXGNFG-UHFFFAOYSA-N
CAS Number
CAS 66701-25-5
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:30270
Target and Pathway
Target(s) Plasmepsin 2 Target Info Inhibitor [538124]
Cathepsin S Target Info Inhibitor [535267]
Cysteine proteinase Target Info Inhibitor [538024]
Plasmepsin 1 Target Info Inhibitor [538124]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Tuberculosis
NetPath Pathway Leptin Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLR
References
Ref 535267Baculoviral expression and characterization of rodent cathepsin S. Protein Expr Purif. 2001 Oct;23(1):45-54.
Ref 535267Baculoviral expression and characterization of rodent cathepsin S. Protein Expr Purif. 2001 Oct;23(1):45-54.
Ref 538024Characterization of a cysteine proteinase from Taenia crassiceps cysts. Mol Biochem Parasitol. 1997 Apr;85(2):243-53.
Ref 538124Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8.

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