| Drug General Information |
| Drug ID |
D09FFE
|
| Former ID |
DIB019994
|
| Drug Name |
H-89
|
| Synonyms |
H 89
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C20H20BrN3O2S
|
| InChI |
InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
|
| InChIKey |
ZKZXNDJNWUTGDK-NSCUHMNNSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
645252, 7888463, 7979494, 10300332, 14833062, 26713167, 26755654, 26755655, 36890876, 46393649, 46515521, 47440048, 47515130, 47662088, 47885222, 48034908, 50064305, 50110953, 50110954, 53788420, 57404912, 74769627, 85787771, 92310080, 99300992, 99302512, 99444466, 103321316, 104051619, 104640657, 124658734, 135078107, 136367926, 137245021, 140309644, 144116047, 152344475, 160969052, 173131097, 178102606, 179113926, 179148593, 184021164, 184589353, 184815477, 198969481, 204371548, 223542506, 226494571, 242462826
|
| Target and Pathway |
| Target(s) |
mRNA of PKA Catalytic Subunit C-alpha |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
MAPK signaling pathway
|
|
Ras signaling pathway
|
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Chemokine signaling pathway
|
|
Oocyte meiosis
|
|
Apoptosis
|
|
Adrenergic signaling in cardiomyocytes
|
|
Vascular smooth muscle contraction
|
|
Wnt signaling pathway
|
|
Hedgehog signaling pathway
|
|
Gap junction
|
|
Platelet activation
|
|
Circadian entrainment
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Cholinergic synapse
|
|
Serotonergic synapse
|
|
GABAergic synapse
|
|
Dopaminergic synapse
|
|
Olfactory transduction
|
|
Taste transduction
|
|
Inflammatory mediator regulation of TRP channels
|
|
Insulin signaling pathway
|
|
Insulin secretion
|
|
GnRH signaling pathway
|
|
Ovarian steroidogenesis
|
|
Progesterone-mediated oocyte maturation
|
|
Estrogen signaling pathway
|
|
Melanogenesis
|
|
Thyroid hormone synthesis
|
|
Thyroid hormone signaling pathway
|
|
Oxytocin signaling pathway
|
|
Glucagon signaling pathway
|
|
Regulation of lipolysis in adipocytes
|
|
Renin secretion
|
|
Endocrine and other factor-regulated calcium reabsorption
|
|
Vasopressin-regulated water reabsorption
|
|
Salivary secretion
|
|
Gastric acid secretion
|
|
Bile secretion
|
|
Parkinson's disease
|
|
Prion diseases
|
|
Cocaine addiction
|
|
Amphetamine addiction
|
|
Morphine addiction
|
|
Alcoholism
|
|
Vibrio cholerae infection
|
|
Amoebiasis
|
|
HTLV-I infection
|
|
Epstein-Barr virus infection
|
|
Pathways in cancer
|
|
Viral carcinogenesis
|
|
Proteoglycans in cancer
|
|
Dilated cardiomyopathy
|
|
PANTHER Pathway
|
Endothelin signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group II pathway
|
|
Metabotropic glutamate receptor group I pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
|
5HT1 type receptor mediated signaling pathway
|
|
Beta1 adrenergic receptor signaling pathway
|
|
Beta2 adrenergic receptor signaling pathway
|
|
Histamine H2 receptor mediated signaling pathway
|
|
GABA-B receptor II signaling
|
|
Dopamine receptor mediated signaling pathway
|
|
Enkephalin release
|
|
Nicotine pharmacodynamics pathway
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
GMCSF-mediated signaling events
|
|
LPA4-mediated signaling events
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
LKB1 signaling events
|
|
Thromboxane A2 receptor signaling
|
|
SHP2 signaling
|
|
Signaling events mediated by HDAC Class I
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
|
Glucocorticoid receptor regulatory network
|
|
ErbB2/ErbB3 signaling events
|
|
IL3-mediated signaling events
|
|
Syndecan-1-mediated signaling events
|
|
Retinoic acid receptors-mediated signaling
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
VEGFR1 specific signals
|
|
Calcium signaling in the CD4+ TCR pathway
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Syndecan-2-mediated signaling events
|
|
Aurora A signaling
|
|
Class I PI3K signaling events mediated by Akt
|
|
Alpha4 beta1 integrin signaling events
|
|
PathWhiz Pathway
|
Muscle/Heart Contraction
|
|
Reactome
|
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
|
|
PKA activation
|
|
PKA activation in glucagon signalling
|
|
DARPP-32 events
|
|
Regulation of PLK1 Activity at G2/M Transition
|
|
Loss of Nlp from mitotic centrosomes
|
|
Recruitment of mitotic centrosome proteins and complexes
|
|
Loss of proteins required for interphase microtubule organization?from the centrosome
|
|
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
|
|
Regulation of insulin secretion
|
|
Vasopressin regulates renal water homeostasis via Aquaporins
|
|
VEGFA-VEGFR2 Pathway
|
|
Interleukin-3, 5 and GM-CSF signaling
|
|
Degradation of GLI1 by the proteasome
|
|
Degradation of GLI2 by the proteasome
|
|
Hedgehog 'off' state
|
|
Anchoring of the basal body to the plasma membrane
|
|
CD209 (DC-SIGN) signaling
|
|
MAPK6/MAPK4 signaling
|
|
Gluconeogenesis
|
|
Factors involved in megakaryocyte development and platelet production
|
|
WikiPathways
|
SIDS Susceptibility Pathways
|
|
Hypothetical Network for Drug Addiction
|
|
Calcium Regulation in the Cardiac Cell
|
|
Endochondral Ossification
|
|
MAPK Signaling Pathway
|
|
G Protein Signaling Pathways
|
|
Myometrial Relaxation and Contraction Pathways
|
|
IL-3 Signaling Pathway
|
|
Mesodermal Commitment Pathway
|
|
Human Complement System
|
|
DAG and IP3 signaling
|
|
Regulation of Water Balance by Renal Aquaporins
|
|
Dopamine metabolism
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
miRs in Muscle Cell Differentiation
|
|
SREBP signalling
|
|
Opioid Signalling
|
|
Mitotic G2-G2/M phases
|
|
Integration of energy metabolism
|
|
Factors involved in megakaryocyte development and platelet production
|
|
Nicotine Activity on Dopaminergic Neurons
|
| References |
| REF 1 | Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem. 1990 Mar 25;265(9):5267-72. |
|---|
