Drug Information

Drug General Information
Drug ID
D09CZS
Former ID
DIB013051
Drug Name
DRF-1042
Synonyms
4(S)-Ethyl-4-hydroxy-12-(2-hydroxyethoxy)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[2,1-b]quinoline-3,14-dione
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [547222]
Structure
Download
2D MOL

3D MOL
Formula
C22H20N2O6
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3C(C4=CC5=CC=CC=C5N=C4C3=C2)OCCO<br />)O
InChI
1S/C22H20N2O6/c1-2-22(28)15-10-17-18-13(9-12-5-3-4-6-16(12)23-18)20(29-8-7-25)24(17)19(26)14(15)11-30-21(22)27/h3-6,9-10,20,25,28H,2,7-8,11H2,1H3/t20?,22-/m0/s1
InChIKey
XAKLYHGHEFMDAP-IAXKEJLGSA-N
CAS Number
CAS 200619-13-2
PubChem Compound ID
23631031
PubChem Substance ID
46492504, 56018897, 140615437, 172649666, 221678785, 233230692, 237169019, 244958051
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [525970], [527487]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 547222Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014200)
Ref 525970Intraperitoneal topoisomerase-I inhibitors. Preliminary findings with 9-aminocamptothecin. Ann N Y Acad Sci. 2000;922:178-87.
Ref 527487Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory cancer patients in a bridging phase I study. J Clin Pharmacol. 2005 Apr;45(4):453-60.

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