Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08ZKN
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| Former ID |
DCL000002
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| Drug Name |
PG-530742
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| Synonyms |
PG 116800; PG 530742; PGE 530742; PGE 7113313; PG-116800
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| Drug Type |
Small molecular drug
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| Indication | Osteoarthritis; Myocardial infarction [ICD9: 410, 715; ICD10:I21, I22, M15-M19, M47] | Discontinued in Phase 2 | [536172] | ||
| Company |
Pharmagenesis
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| Structure |
|
Download2D MOL |
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| Formula |
C23H25N3O7S
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| Canonical SMILES |
COC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC(C#CCN3CCO<br />CC3)C(=O)O
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| InChI |
1S/C23H25N3O7S/c1-32-19-8-4-17(5-9-19)22(27)24-18-6-10-20(11-7-18)34(30,31)25-21(23(28)29)3-2-12-26-13-15-33-16-14-26/h4-11,21,25H,12-16H2,1H3,(H,24,27)(H,28,29)
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| InChIKey |
WJDDDFUBTYNDPP-UHFFFAOYSA-N
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| CAS Number |
CAS 291533-11-4
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Stromelysin-1 | Target Info | Inhibitor | [528049], [536172] | |
| NetPath Pathway | IL1 Signaling Pathway | ||||
| IL4 Signaling Pathway | |||||
| PANTHER Pathway | Plasminogen activating cascade | ||||
| CCKR signaling map ST | |||||
| References | |||||
| Ref 528049 | Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 2006 Mar;6(3):227-39. | ||||
| Ref 536172 | Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7. Epub 2006 Jan 20. | ||||
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