Drug Information

Drug General Information
Drug ID
D08WBB
Former ID
DIB018948
Drug Name
BAY-73-1449
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541161]
Structure
Download
2D MOL
Formula
C26H23N3O3
InChI
InChI=1S/C26H23N3O3/c30-26(31)24(15-19-7-3-1-4-8-19)29-25-16-23(27-18-28-25)21-11-13-22(14-12-21)32-17-20-9-5-2-6-10-20/h1-14,16,18,24H,15,17H2,(H,30,31)(H,27,28,29)/t24-/m0/s1
InChIKey
RRYFPNITZGCUPZ-DEOSSOPVSA-N
PubChem Compound ID
11743147
PubChem Substance ID
16849769, 23827330, 42785199, 74684614, 139103883, 178102475, 231684283, 243460077
Target and Pathway
Target(s) Prostacyclin receptor Target Info Antagonist [529584]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 541161(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5851).
Ref 529584Vascular actions of the prostacyclin receptor antagonist BAY 73-1449 in the portal hypertensive rat. Eur J Pharmacol. 2008 Aug 20;590(1-3):322-6.

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