Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08VMW
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| Former ID |
DIB015816
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| Drug Name |
MP-529
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| Synonyms |
SGI-1097; SGI-1215; SGI-498; SGI-503; Oral aurora kinase inhibitor (cancer), Montigen
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
| Company |
Montigen Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
O=S(=O)(c1ccc(NC(=S)N2CCN(c3ncnc4c3c3c(cc(c(c3)OC)OC)[n<br />H]4)CC2)cc1)Nc1ccc(cc1)F
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| Target and Pathway | |||||
| Target(s) | Aurora protein kinase | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Oocyte meiosis | ||||
| Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
| Separation of Sister Chromatids | |||||
| Resolution of Sister Chromatid Cohesion | |||||
| RHO GTPases Activate Formins | |||||
| WikiPathways | EGF/EGFR Signaling Pathway | ||||
| JAK/STAT | |||||
| Gastric Cancer Network 1 | |||||
| Integrated Breast Cancer Pathway | |||||
| APC/C-mediated degradation of cell cycle proteins | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). | ||||
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