Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08TSE
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| Former ID |
DNC009761
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| Drug Name |
1-Acetoxy-2-tert-butyldimethylsilyl-oxylycorine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H33NO5Si
|
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| Canonical SMILES |
CC(=O)OC1C(C=C2CCN3C2C1C4=CC5=C(C=C4C3)OCO5)O[Si](C)(C)<br />C(C)(C)C
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| InChI |
1S/C24H33NO5Si/c1-14(26)29-23-20(30-31(5,6)24(2,3)4)9-15-7-8-25-12-16-10-18-19(28-13-27-18)11-17(16)21(23)22(15)25/h9-11,20-23H,7-8,12-13H2,1-6H3/t20-,21-,22+,23+/m0/s1
|
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| InChIKey |
IQOBLYMQXROOIM-MYDTUXCISA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Cytochrome P450 3A4 | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Linoleic acid metabolism | |||||
| Retinol metabolism | |||||
| Metabolism of xenobiotics by cytochrome P450 | |||||
| Drug metabolism - cytochrome P450 | |||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathways | |||||
| Bile secretion | |||||
| Chemical carcinogenesis | |||||
| PathWhiz Pathway | Caffeine Metabolism | ||||
| Retinol Metabolism | |||||
| Reactome | Xenobiotics | ||||
| Aflatoxin activation and detoxification | |||||
| WikiPathways | Metapathway biotransformation | ||||
| Aflatoxin B1 metabolism | |||||
| Estrogen metabolism | |||||
| Benzo(a)pyrene metabolism | |||||
| Tamoxifen metabolism | |||||
| Tryptophan metabolism | |||||
| Oxidation by Cytochrome P450 | |||||
| Nuclear Receptors in Lipid Metabolism and Toxicity | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Farnesoid X Receptor Pathway | |||||
| Vitamin D Receptor Pathway | |||||
| Felbamate Metabolism | |||||
| Lidocaine metabolism | |||||
| Nifedipine Activity | |||||
| Colchicine Metabolic Pathway | |||||
| Irinotecan Pathway | |||||
| Drug Induction of Bile Acid Pathway | |||||
| Fatty Acid Omega Oxidation | |||||
| Codeine and Morphine Metabolism | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2009 Jun 15;19(12):3233-7. Epub 2009 Apr 24.Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. | ||||
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