Drug Information
Drug General Information | |||||
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Drug ID |
D08SEI
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Former ID |
DAP000335
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Drug Name |
Levocabastine
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Synonyms |
Levocabastin; Levocabastina; Levocabastinum; Livostin; Levocabastina [Spanish]; Levocabastinum [Latin]; Levocabastine (INN); Levocabastine [INN:BAN]; Livostin (TN); (3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid; 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-4-piperidinecarboxylic acid
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Drug Type |
Small molecular drug
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Therapeutic Class |
Antiallergic Agents
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Company |
Janssen Pharmaceutica
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Structure |
Download2D MOL |
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Formula |
C26H29FN2O2
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InChI |
InChI=1S/C26H29FN2O2/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20/h2-10,19,23H,11-17H2,1H3,(H,30,31)/t19-,23-,25-,26-/m1/s1
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InChIKey |
ZCGOMHNNNFPNMX-KYTRFIICSA-N
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CAS Number |
CAS 79516-68-0
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PubChem Compound ID | |||||
PubChem Substance ID |
7979772, 11467067, 11468187, 11486844, 14807001, 15501039, 32961388, 34718386, 46505909, 47349573, 47573562, 47646743, 47795244, 49699381, 50065214, 50123948, 50473844, 57313613, 85788903, 96024807, 104304776, 124893604, 126666083, 134221875, 134337647, 135257219, 135650515, 136081779, 137005452, 137263743, 160964440, 163693550, 163852910, 175265815, 176484508, 179116755, 180191810, 194168802, 198974741, 223532782, 223681847, 226396552, 226517688, 242042090, 248745270
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SuperDrug ATC ID |
R01AC02; S01GX02
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SuperDrug CAS ID |
cas=079516680
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Target and Pathway | |||||
Target(s) | Histamine H1 receptor | Target Info | Antagonist | [535848], [536800] | |
PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
References | |||||
Ref 536119 | Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20. | ||||
Ref 538963 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1586). | ||||
Ref 535848 | Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules. J Allergy Clin Immunol. 2003 Oct;112(4 Suppl):S78-82. | ||||
Ref 536800 | Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine. Biochem Pharmacol. 2008 Sep 15;76(6):751-62. Epub 2008 Jul 15. |
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