Drug Information

Drug General Information
Drug ID
D08NXC
Former ID
DNC014184
Drug Name
1-[(Furan-2(5H)-one)-4-methyl]-desloratadine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530666]
Structure
Download
2D MOL

3D MOL
Formula
C24H23ClN2O2
Canonical SMILES
C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)CC4=CC(=O)OC4)C5=C1C=C<br />C=N5
InChI
1S/C24H23ClN2O2/c25-20-5-6-21-19(13-20)4-3-18-2-1-9-26-24(18)23(21)17-7-10-27(11-8-17)14-16-12-22(28)29-15-16/h1-2,5-6,9,12-13H,3-4,7-8,10-11,14-15H2
InChIKey
CHEQBNZJRBHHQT-UHFFFAOYSA-N
PubChem Compound ID
46233181
Target and Pathway
Target(s) Histamine H1 receptor Target Info Inhibitor [530666]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530666Bioorg Med Chem. 2010 Feb 15;18(4):1626-32. Epub 2010 Jan 4.Stereoselective synthesis of desloratadine derivatives as antagonist of histamine.
Ref 530666Bioorg Med Chem. 2010 Feb 15;18(4):1626-32. Epub 2010 Jan 4.Stereoselective synthesis of desloratadine derivatives as antagonist of histamine.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.