Drug Information
Drug General Information | |||||
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Drug ID |
D08NTB
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Former ID |
DNC008393
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Drug Name |
LFM-A13
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529213] | ||
Structure |
Download2D MOL |
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Formula |
C11H8Br2N2O2
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Canonical SMILES |
CC(=C(C#N)C(=O)NC1=C(C=CC(=C1)Br)Br)O
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InChI |
1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6-
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InChIKey |
UVSVTDVJQAJIFG-VURMDHGXSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Tyrosine-protein kinase BTK | Target Info | Inhibitor | [529213] | |
PANTHER Pathway | B cell activation | ||||
PathWhiz Pathway | Fc Epsilon Receptor I Signaling in Mast Cells | ||||
Reactome | MyD88:Mal cascade initiated on plasma membrane | ||||
Regulation of actin dynamics for phagocytic cup formation | |||||
DAP12 signaling | |||||
FCERI mediated Ca+2 mobilization | |||||
MyD88 deficiency (TLR2/4) | |||||
IRAK4 deficiency (TLR2/4) | |||||
RHO GTPases Activate WASPs and WAVEs | |||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | |||||
References |
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