Drug General Information
Drug ID
D08LQD
Former ID
DIB002843
Drug Name
RESEQUINIL
Synonyms
AVE-3933; SX-3933; Resequinil < Prop INN >; 5-(3-Methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1,6-naphthyridin-2(1H)-one
Drug Type
Small molecular drug
Indication Epilepsy [ICD10:G40] Discontinued in Phase 2 [546863]
Structure
Download
2D MOL

3D MOL

Formula
C18H14N4O3
Canonical SMILES
COc1cccc(c1)c2nccc3NC(=O)C(=Cc23)c4noc(C)n4
InChI
1S/C18H14N4O3/c1-10-20-17(22-25-10)14-9-13-15(21-18(14)23)6-7-19-16(13)11-4-3-5-12(8-11)24-2/h3-9H,1-2H3,(H,21,23)
InChIKey
JQOFKKWHXGQABB-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) GABA A receptor Target Info Agonist [550144]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 546863Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010724)
Ref 550144WO patent application no. 2010,0024,51, Naphthyridin derivatives.

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