Drug Information

Drug General Information
Drug ID
D08LDS
Former ID
DNC012213
Drug Name
LUBELUZOLE
Drug Type
Small molecular drug
Indication Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10:I21, I22, R52, R52.1-R52.2, R60.9, G89] Discontinued in Preregistration [545928]
Structure
Download
2D MOL

3D MOL
Formula
C22H25F2N3O2S
Canonical SMILES
CN(C1CCN(CC1)CC(COC2=CC(=C(C=C2)F)F)O)C3=NC4=CC=CC=C4S3
InChI
1S/C22H25F2N3O2S/c1-26(22-25-20-4-2-3-5-21(20)30-22)15-8-10-27(11-9-15)13-16(28)14-29-17-6-7-18(23)19(24)12-17/h2-7,12,15-16,28H,8-11,13-14H2,1H3/t16-/m0/s1
InChIKey
OZFSWVOEXHGDES-INIZCTEOSA-N
CAS Number
CAS 144665-07-6
PubChem Compound ID
65998
Target and Pathway
Target(s) Sodium channel Target Info Inhibitor [525961]
Sodium channel protein type 5 subunit alpha Target Info Inhibitor [525961]
KEGG Pathway Dopaminergic synapsehsa04261:Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 545928Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005388)
Ref 525961J Med Chem. 2001 Jan 18;44(2):115-37.Medicinal chemistry of neuronal voltage-gated sodium channel blockers.

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