| Drug General Information |
| Drug ID |
D08KLH
|
| Former ID |
DIB018402
|
| Drug Name |
[3H]RX821002
|
| Synonyms |
[3H]2-methoxyidazoxan
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H14N2O3
|
| InChI |
InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14)
|
| InChIKey |
HQGWKNGAKBPTBX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
840954, 842020, 7536812, 7980550, 10234596, 11364712, 11367274, 11369836, 11378000, 11495622, 14749421, 44436992, 47572603, 48168573, 48393132, 49979496, 50104814, 57338437, 76822660, 85209706, 85788141, 90341601, 103169829, 103930440, 104380489, 124750201, 124881351, 128097672, 134224937, 134349649, 135066174, 135650954, 135651200, 136905176, 140884806, 141391967, 152253110, 162169298, 179236103, 228600997
|
| Target and Pathway |
| Target(s) |
Alpha-2C adrenergic receptor |
Target Info |
Antagonist |
[2]
|
|---|
| Alpha-2B adrenergic receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Reactome
|
Adrenoceptors
|
|
Adrenaline signalling through Alpha-2 adrenergic receptor
|
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Adrenaline,noradrenaline inhibits insulin secretion
|
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G alpha (i) signalling events
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G alpha (z) signalling events
|
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Surfactant metabolismR-HSA-390696:Adrenoceptors
|
|
WikiPathways
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Platelet Aggregation (Plug Formation)
|
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Integration of energy metabolism
|
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GPCR ligand binding
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
|
GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 528). |
|---|
| REF 2 | Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs. Eur J Pharmacol. 1994 Jan 24;252(1):43-9. |
|---|
