Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08JNE
|
||||
| Former ID |
DNCL003101
|
||||
| Drug Name |
RG1578
|
||||
| Indication | Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] | Discontinued in Phase 2 | [1] | ||
| Company |
Roche
|
||||
| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 2 | Target Info | Modulator | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Glutamatergic synapse | |||||
| Cocaine addiction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group II pathway | |||||
| Reactome | G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034342) | ||||
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