Drug General Information
Drug ID
D08HXG
Former ID
DIB006326
Drug Name
PMX-60056
Synonyms
PMX-150; PMX-60054; PMX-60065; PMX-60077; PMX-60079; PMX-60087; PMX-640; PMX-686; PMX-747; PMX-801; Heparin andlow molecular weight heparin (LMWH) reversing agents, PolyMedix
Drug Type
Small molecular drug
Indication Blood coagulation disorders [ICD10:D65-D68] Phase 2 [523389]
Company
PolyMedix Inc
Structure
Download
2D MOL

3D MOL

Formula
C56H79N13O12
Canonical SMILES
COC1=C(C=C(C=C1)NC(=O)C(CCCCN)N)C(=O)NC(CCCCN)C(=O)NC2=<br />CC(=C(C=C2)OC)C(=O)NC(CCCCN)C(=O)NC3=CC(=C(C=C3)OC)C(=O<br />)NC(CCCCN)C(=O)NC4=CC(=C(C=C4)OC)C(=O)N
InChI
1S/C56H79N13O12/c1-78-45-21-17-33(29-37(45)49(62)70)64-54(75)42(14-6-10-26-58)67-51(72)39-31-35(19-23-47(39)80-3)66-56(77)44(16-8-12-28-60)69-52(73)40-32-36(20-24-48(40)81-4)65-55(76)43(15-7-11-27-59)68-50(71)38-30-34(18-22-46(38)79-2)63-53(74)41(61)13-5-9-25-57/h17-24,29-32,41-44H,5-16,25-28,57-61H2,1-4H3,(H2,62,70)(H,63,74)(H,64,75)(H,65,76)(H,66,77)(H,67,72)(H,68,71)(H,69,73)/t41-,42-,43-,44-/m0/s1
InChIKey
PWFIFNGOPQUNIT-ITMZJIMRSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Antithrombin-III Target Info Antagonist [544218]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
Pathway Interaction Database Glypican 1 network
Reactome Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
WikiPathways Complement and Coagulation Cascades
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 523389ClinicalTrials.gov (NCT01312935) Reversal of Heparin in Patients Undergoing Percutaneous Coronary Intervention (PCI). U.S. National Institutes of Health.
Ref 544218Parenteral Anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Correction in: Chest. 2013 August; 144(2): 721.

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