Drug General Information
Drug ID
D08FTG
Former ID
DAP000769
Drug Name
Phenindione
Synonyms
Athrombon; Bindan; Cronodione; Danedion; Danilon; Danilone; Diadilan; Dindevan; Dineval; Diophindane; Emandion; Emandione; Eridione; Fenhydren; Fenilin; Fenindion; Fenindiona; Hedulin; Hemolidione; Indema; Indion; Indon; Phenhydren; Phenillin; Phenindionum; Phenylen; Phenylin; Phenylindanedione; Phenylindione; Phenyline; Phenyllin; Pindione; Rectadione; Theradione; Thrombasal; Tromazal; Trombol; Boots Brand of Phenindione; Goldshield Brand of Phenindione; Merck Lipha Sante Brand of Phenindione; P1029; P26406_ALDRICH; Fenindiona [INN-Spanish]; Hedulin (TN); Phenindione (INN); Phenindione [INN:BAN]; Phenindionum [INN-Latin]; 2 Phenyl 1,3 indandione; 2-Fenyloindandion-1,3; 2-Fenyloindandion-1,3 [Polish]; 2-Phenyl-1,3-diketohydrindene; 2-Phenyl-1,3-indandione; 2-Phenyl-1,3-indanedione; 2-Phenyl-1H-indene-1,3(2H)-dione; 2-Phenylindan-1,3-dione; 2-Phenylindandione; 2-phenyl-1,3(2H)-Indenedione; 2-phenyl-2,3-dihydro-1H-indene-1,3-dione; 2-phenylindene-1,3-dione
Drug Type
Small molecular drug
Indication Pulmonary embolism; Blood clotting disorder [ICD9: 415.1, 286; ICD10:I26, D65-D69] Approved [541918], [550721], [551871]
Therapeutic Class
Anticoagulants
Structure
Download
2D MOL

3D MOL

Formula
C15H10O2
InChI
InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H
InChIKey
NFBAXHOPROOJAW-UHFFFAOYSA-N
CAS Number
CAS 83-12-5
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:8066
SuperDrug ATC ID
B01AA02
SuperDrug CAS ID
cas=000083125
Target and Pathway
Target(s) Vitamin K epoxide reductase complex subunit 1 Target Info Inhibitor [536520]
KEGG Pathway Ubiquinone and other terpenoid-quinone biosynthesis
PathWhiz Pathway Vitamin K Metabolism
Coagulation
WikiPathways PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
References
Ref 541918(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6838).
Ref 550721Drug information of Phenindione, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536520Oral anticoagulation and pharmacogenetics: importance in the clinical setting. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036.

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