| Drug General Information |
| Drug ID |
D08EFH
|
| Former ID |
DNC004114
|
| Drug Name |
2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine
|
| Synonyms |
5-methoxy-alpha-methyltryptamine
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
CC(CC1=CNC2=C1C=C(C=C2)OC)N
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| InChI |
1S/C12H16N2O/c1-8(13)5-9-7-14-12-4-3-10(15-2)6-11(9)12/h3-4,6-8,14H,5,13H2,1-2H3
|
| InChIKey |
OGNJZVNNKBZFRM-UHFFFAOYSA-N
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| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2C receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[2]
|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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Calcium signaling pathway
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Neuroactive ligand-receptor interaction
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Gap junction
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Serotonergic synapse
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Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
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Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
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Serotonergic synapsehsa04020:Calcium signaling pathway
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Inflammatory mediator regulation of TRP channels
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PANTHER Pathway
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5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
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Reactome
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Serotonin receptors
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (q) signalling events
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WikiPathways
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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SIDS Susceptibility Pathways
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GPCR downstream signaling
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GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
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GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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| References |
| REF 1 | J Med Chem. 2006 Jan 12;49(1):318-28.1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
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| REF 2 | J Med Chem. 2003 Sep 11;46(19):4188-95.A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
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