Drug Information

Drug General Information
Drug ID
D07XXX
Former ID
DNC013038
Drug Name
Tyr-Pro-Phe-Hfe-NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528190]
Structure
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2D MOL

3D MOL
Formula
C33H39N5O5
Canonical SMILES
C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CC=CC=C3<br />)C(=O)NC(CCC4=CC=CC=C4)C(=O)N
InChI
1S/C33H39N5O5/c34-26(20-24-13-16-25(39)17-14-24)33(43)38-19-7-12-29(38)32(42)37-28(21-23-10-5-2-6-11-23)31(41)36-27(30(35)40)18-15-22-8-3-1-4-9-22/h1-6,8-11,13-14,16-17,26-29,39H,7,12,15,18-21,34H2,(H2,35,40)(H,36,41)(H,37,42)/t26-,27-,28-,29-/m0/s1
InChIKey
KEZWZCZPOVYKBN-DZUOILHNSA-N
PubChem Compound ID
14991612
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [528190]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 528190Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. Epub 2006 May 8.Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics inthe position 3 or 4.
Ref 528190Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. Epub 2006 May 8.Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics inthe position 3 or 4.

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