Drug Information

Drug General Information
Drug ID
D07VWT
Former ID
DIB003680
Drug Name
Platelet activating factor receptor inhibitors
Synonyms
Platelet activating factor receptor inhibitors (pain); Platelet activating factor receptor inhibitors (pain), Merck & Co
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [552146]
Company
Merck & Co Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
FC(F)(c1cc(C(F)(F)F)cc(c2ccc(cc2)C(=O)N2CCC(C2)c2cnccc2<br />)c1)F
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Inhibitor [543773]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 552146Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. Proc Natl Acad Sci U S A. 1985 Feb;82(3):672-6.
Ref 543773(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 334).

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