Drug Information

Drug General Information
Drug ID
D07VBS
Former ID
DIB018718
Drug Name
A412997
Synonyms
A-412,997; A-412997
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540263]
Structure
Download
2D MOL
Formula
C19H23N3O
InChI
InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23)
InChIKey
JFCDMGGMCUKHST-UHFFFAOYSA-N
PubChem Compound ID
10425450
PubChem Substance ID
15444520, 22767519, 40553121, 50077139, 76339788, 103503918, 104080476, 143497569, 152239766, 162219910, 163642496, 178100338, 196372072, 198986120, 202555796, 223573725, 229975908, 247873598
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Agonist [527731]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 540263(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3301).
Ref 527731A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol Biochem Behav. 2005 Sep;82(1):140-7. Epub 2005 Sep 8.

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