TTD | Drug: D07TWQ

Drug General Information
Drug ID	D07TWQ
Former ID	DIB020618
Drug Name	ONO-AE5-599
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541142]
Structure		Download 2D MOL
Formula	C32H39NO3
InChI	InChI=1S/C32H39NO3/c1-21(2)15-30(28-17-22(3)16-23(4)18-28)33-25(6)29-19-26(11-12-27(29)13-14-32(34)35)20-36-31-10-8-7-9-24(31)5/h7-12,16-19,21,30,33H,6,13-15,20H2,1-5H3,(H,34,35)/t30-/m1/s1
InChIKey	MIHNFQDPLQJFEZ-SSEXGKCCSA-N
PubChem Compound ID	73755159
PubChem Substance ID	178102448
Target and Pathway
Target(s)	Prostaglandin E2 receptor EP3 subtype	Target Info	Antagonist	[528849]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Regulation of lipolysis in adipocytes
	Pathways in cancer
NetPath Pathway	IL2 Signaling Pathway
Reactome	Prostanoid ligand receptors
Reactome	G alpha (i) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541142	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5823).
Ref 528849	Involvement of prostaglandin E receptor EP3 subtype in duodenal bicarbonate secretion in rats. Life Sci. 2007 Jun 6;80(26):2446-53. Epub 2007 Apr 21.

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Drug Information