Drug Information

Drug General Information
Drug ID
D07QWZ
Former ID
DIB006936
Drug Name
AZT-P-DDI
Synonyms
Scriptene; IVX-E-59; 3'-Azido-3'-deoxythymidylyl-(5',5')-2',3'-dideoxy-5'-inosinic acid; 3'-Azido-3'-deoxythymidylyl-(5'-5')-2',3'-dideoxyinosine
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 2 [546009]
Structure
Download
2D MOL

3D MOL
Formula
C20H24N9O9P
Canonical SMILES
CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OCC3CCC(O3)N4C=NC<br />5=C4NC=NC5=O)N=[N+]=[N-]
InChI
1S/C20H24N9O9P/c1-10-5-28(20(32)25-18(10)30)15-4-12(26-27-21)13(38-15)7-36-39(33,34)35-6-11-2-3-14(37-11)29-9-24-16-17(29)22-8-23-19(16)31/h5,8-9,11-15H,2-4,6-7H2,1H3,(H,33,34)(H,22,23,31)(H,25,30,32)/t11-,12-,13+,14+,15+/m0/s1
InChIKey
XURFYCWNUGWGDL-VQJWOFKYSA-N
CAS Number
CAS 121135-53-3
PubChem Compound ID
158439
PubChem Substance ID
596058, 14812989, 46233868, 57348504, 77321974, 113439919, 135112884, 198964227
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [534200], [551871]
References
Ref 546009Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005869)
Ref 534200Antiviral activities of nucleotide heterodimers against human immunodeficiency virus type 1 in vitro. Antiviral Res. 1996 Jun;31(1-2):115-20.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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