Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07QMR
|
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| Former ID |
DNC013293
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| Drug Name |
N-(1-(4-phenylbutyl)piperidin-4-yl)-1-naphthamide
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C26H30N2O
|
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| Canonical SMILES |
C1CN(CCC1NC(=O)C2=CC=CC3=CC=CC=C32)CCCCC4=CC=CC=C4
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| InChI |
1S/C26H30N2O/c29-26(25-15-8-13-22-12-4-5-14-24(22)25)27-23-16-19-28(20-17-23)18-7-6-11-21-9-2-1-3-10-21/h1-5,8-10,12-15,23H,6-7,11,16-20H2,(H,27,29)
|
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| InChIKey |
JATDEOORDLHCRO-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 2A receptor | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | ||||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| SIDS Susceptibility Pathways | |||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors. | ||||
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