Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07QCE
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| Former ID |
DAP000782
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| Drug Name |
Azathioprine
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| Synonyms |
Azamun; Azanin; Azasan; Azathioprin; Azathioprinum; Azathiopurine; Azatioprin; Azatioprina; Azothioprine; Ccucol; Cytostatics; Immuran; Imuran; Imurek; Imurel; Methylnitroimidazolylmercaptopurine; Muran; Azamun [Czech]; Azathioprine sodium; Azatiopr in; A 4638; BW 57322; Azamun (TN); Azasan (TN); Azathioprinum [INN-Latin]; Azatioprina [INN-Spanish]; BW 57-322; Imuran (TN); Imurel (TN); [Methyl(nitroimidazolyl)mercaptopurine]; AI-981/34845012; BW-57-322; Azathioprine (JP15/USP/INN); Azathioprine [USAN:INN:BAN:JAN]; B. W. 57-322; Thiopurine 6-(1-methyl-4-nitroimidazol-5-yl); Azasan, Imuran, Azamun, BW-57-322, NSC-39084, Azathioprine; 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine; 6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)mercaptopurine; 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine; 6-(1-Methyl-4-nitroimidazol-5-ylthio)purin; 6-(1-Methyl-4-nitroimidazol-5-ylthio)purin [Czech]; 6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine; 6-(1-Methyl-p-nitro-5-imidazolyl)thiopurine; 6-(3-Methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-7H-purine; 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine; 6-(Methyl-p-nitro-5-imidazolyl)-thiopurine; 6-(Methyl-p-nitro-5-imidazolyl)thiopurine; 6-({4-nitro-1-methyl-1H-imidazol-5-yl}sulfanyl)-7H-purine; 6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine; 6-[(1-Methyl-4-nitroimidazol-5-yl)-thio] purine; 6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-Purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-7H-purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Immunosuppressive Agents
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| Company |
GlaxoSmithKline
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| Structure |
|
Download2D MOL |
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| Formula |
C9H7N7O2S
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| InChI |
InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)
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| InChIKey |
LMEKQMALGUDUQG-UHFFFAOYSA-N
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| CAS Number |
CAS 446-86-6
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9055, 545491, 4476272, 4486208, 4503338, 7592075, 7695226, 7847305, 7978746, 8149210, 8151523, 10321142, 10560483, 10584680, 11110740, 11110741, 11142069, 11335761, 11361000, 11362878, 11364839, 11365440, 11367401, 11368002, 11369963, 11371476, 11373003, 11373785, 11375563, 11376164, 11378131, 11461972, 11466122, 11467242, 11483991, 11485723, 11487884, 11490124, 11492058, 11493878, 11524329, 11533962, 11536345, 12294767, 14775167, 14824335, 15222101, 17390031, 17404591, 24278074
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| ChEBI ID |
ChEBI:2948
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| SuperDrug ATC ID |
L04AX01
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| SuperDrug CAS ID |
cas=000446866
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| Target and Pathway | |||||
| Target(s) | Inosine-5'-monophosphate dehydrogenase 1 | Target Info | Inhibitor | [536171], [536460] | |
| PathWhiz Pathway | Purine Metabolism | ||||
| WikiPathways | Nucleotide Metabolism | ||||
| References | |||||
| Ref 536737 | Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. | ||||
| Ref 542128 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7120). | ||||
| Ref 536171 | Immunosuppressive drugs and renal transplantation. G Ital Nefrol. 2005 Nov-Dec;22 Suppl 33:S76-9. | ||||
| Ref 536460 | IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br J Clin Pharmacol. 2008 Jan;65(1):69-77. Epub 2007 Jul 27. | ||||
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