| Drug General Information |
| Drug ID |
D07QBQ
|
| Former ID |
DNC012277
|
| Drug Name |
6-Chloro-1,4-dihydro-quinoxaline-2,3-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H5ClN2O2
|
| Canonical SMILES |
C1=CC2=C(C=C1Cl)NC(=O)C(=O)N2
|
| InChI |
1S/C8H5ClN2O2/c9-4-1-2-5-6(3-4)11-8(13)7(12)10-5/h1-3H,(H,10,12)(H,11,13)
|
| InChIKey |
RNOLFZACEWWIHP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[1]
|
| NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
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Rap1 signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Circadian entrainment
|
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Long-term potentiation
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Glutamatergic synapse
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Dopaminergic synapse
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholism
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Systemic lupus erythematosushsa04014:Ras signaling pathway
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Calcium signaling pathway
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PANTHER Pathway
|
Huntington disease
|
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Pathway Interaction Database
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ErbB4 signaling events
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Reelin signaling pathwayreelinpathway:Reelin signaling pathway
|
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Reactome
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EPHB-mediated forward signaling
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
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Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers Disease
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| References |
| REF 1 | J Med Chem. 1997 Oct 24;40(22):3679-86.5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
|---|
