Drug General Information
Drug ID
D07NAJ
Former ID
DAP000131
Drug Name
Chloroprocaine
Synonyms
Chloroprocain; Chloroprocainum; Chlorprocaine; Chlorprocainum; Cloroprocaina; Halestyn; Nesacaine; Piocaine; Chloroprocaine [INN]; Chloroprocaine hydrochloride; Nesacaine MPF; Chlor-procaine; Chloroprocaine (INN); Chloroprocainum [INN-Latin]; Cloroprocaina [INN-Spanish]; Nesacaine (TN); Nesacaine-Ce; Nesacaine-MPF (TN); Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester; 2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate; 2-(Diethylaminoethyl)-4-amino-2-chlorobenzoate; 2-Chloroprocaine; 2-diethylaminoethyl 4-amino-2-chlorobenzoate; 4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
Drug Type
Small molecular drug
Indication Anesthesia [ICD9: 338; ICD10:R20.0] Approved [538175], [542152]
Therapeutic Class
Anesthetics
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL

Formula
C13H19ClN2O2
InChI
InChI=1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
InChIKey
VDANGULDQQJODZ-UHFFFAOYSA-N
CAS Number
CAS 133-16-4
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
N01BA04
SuperDrug CAS ID
cas=000133164
Target and Pathway
Target(s) Sodium/potassium-transporting ATPase alpha-1 chain Target Info Blocker [535175]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Proximal tubule bicarbonate reclamation
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Protein digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Kidney Function
Lactose Degradation
Trehalose Degradation
Muscle/Heart Contraction
Reactome Ion transport by P-type ATPases
WikiPathways Iron uptake and transport
References
Ref 538175FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040273.
Ref 542152(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7145).
Ref 535175Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403.

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