Drug General Information
Drug ID	D07JSK
Former ID	DIB004697
Drug Name	Sulotroban
Synonyms	BM-13177; SKF-95587
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[544519]
Company	Boehringer Mannheim GmbH
Structure		Download 2D MOL 3D MOL
Formula	C16H17NO5S
Canonical SMILES	S(=O)(=O)(c1ccccc1)NCCc1ccc(OCC(=O)O)cc1
CAS Number	CAS 72131-33-0
PubChem Compound ID	51550
Target and Pathway
Target(s)	Thromboxane A2 receptor	Target Info	Modulator	[532727]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
	Thromboxane signalling through TP receptor
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544519	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000039)
Ref 532727	The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation. Prostaglandins. 1988 Dec;36(6):751-60.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.