Drug Information

Drug General Information
Drug ID
D07IZR
Former ID
DNC000197
Drug Name
AMG-126737
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535361]
Structure
Download
2D MOL

3D MOL
Formula
C33H38N6O6S2
Canonical SMILES
C1=CC(=CC(=C1)S(=O)(=O)CNC2=CC=C(C=C2)OCCCCCOC3=CC=C(C=<br />C3)CNS(=O)(=O)C4=CC=CC(=C4)C(=N)N)C(=N)N
InChI
1S/C33H38N6O6S2/c34-32(35)25-6-4-8-30(20-25)46(40,41)23-38-27-12-16-29(17-13-27)45-19-3-1-2-18-44-28-14-10-24(11-15-28)22-39-47(42,43)31-9-5-7-26(21-31)33(36)37/h4-17,20-21,38-39H,1-3,18-19,22-23H2,(H3,34,35)(H3,36,37)
InChIKey
VYMJOZRWSKPFHN-UHFFFAOYSA-N
CAS Number
CAS 224054-76-6
PubChem Compound ID
56603750
PubChem Substance ID
134339699
Target and Pathway
Target(s) Tryptase Target Info Inhibitor [535361]
Reactome Activation of Matrix Metalloproteinases
References
Ref 535361Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000.
Ref 535361Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000.

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